Invited Review Articles

Oxidize me to the space. 

Yang J

Nat Chem Biol. 2022, 18(7): 680–681, Link

Sweetly profiling the cysteinome. 

Yang J

Nat Chem Biol. 2019, 15(10): 935-936  Link

Mapping the cysteine redoxome: advances and prospects (in Chinese)

Yang J

Sci Sin Vitae, 2021, 51, DOI: 10.1360/SSV-2020-0393

Representative Research Articles
*Corresponding author,
Co-first author

Nucleophilic covalent ligand discovery for the cysteine redoxome.

Fu L†, Jung Y†, Tian C, Ferreira R, Cheng R, He F, Yang J*, Carroll KS*.

Nat Chem Biol, 2023, 19(11): 1309-1319 Link  (Featured by NCB's News & Views)

A modification-centric assessment tool for the performance of chemoproteomic probes.

He J†, Fei Z†, Fu L, Tian C, He F, Chi H*, Yang J*.

Nat Chem Biol, 2022, 18(8): 904-912 Link  (Featured by NCB's News & Views)

Wittig reagents for chemoselective sulfenic acid ligation enables global site stoichiometry analysis and redox-controlled mitochondrial targeting.

Shi Y , Fu LYang J*, Carroll KS*.

Nat Chem, 2021, 13: 1140-1150. Link  (Highlighted by Nat Chem Biol)

The cytosolic thiol peroxidase PRXIIB is an intracellular sensor for H2O2 that regulates plant immunity through a redox relay
Bi G † , Hu M † , Fu L † , Zhang X, Zuo J, Li J, Yang J* , Zhou JM*.
Nat Plants
, 2022, 8(10): 1160-1175. Link (Featured by Nat Plants' News & Views)

Global profiling of distinct cysteine redox forms reveals wide-ranging redox regulation in C. elegans.
Meng J† , Fu L†, Liu K, Tian C, Wu Z, Jung Y, Ferreira R, Carroll KS, Blackwell TK*, Yang J*.

Nat Commun, 2021, 12: 1415. Link

A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells.

Wang M† , He JY† , He JX, Liu K, Yang J*.

Chem Sci, 2021, 12: 14557-14563. Link

A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes.

Fu L†, Li Z†, Tian C†, Liu K†, He JX, He JY, He F, Xu P, Yang J*.

Nat Protoc, 2020, 15(9): 2891-2919. Link

Direct proteomic mapping of cysteine persulfidation.

Fu L†, Liu K†, He J, Tian C, Yu X, Yang J*.

Antioxid Redox Signal. 2020, 33(15): 1061-1076  Link

Chemical Proteomics Reveals New Targets of Cysteine Sulfinic Acid Reductase.

Akter S†, Fu L†, Jung Y, Lo Conte M, Lawson JR, Lowther TW, Sun R, Liu K, Yang J*, Carroll KS*.

Nat Chem Biol. 2018, 14 (11): 995-1004 Link (Featured by NCB's News & Views & Nat Methods's Research Highlights In Brief)

Multiplexed Thiol Reactivity Profiling for Target Discovery of Electrophilic Natural Products. 

Tian C, Fu L, Liu K, Sun R, Yang Y, Yang J*

Cell Chem Biol, 2017, 24(11):1416-1427 Link

Chemoproteomics Reveals Chemical Diversity and Dynamics of 4-Oxo-2-nonenal Modifications in Cells.

Sun R†, Fu L†, Liu K, Tian C, Yang Y, Tallman KA, Porter NA, Liebler DC, Yang J*.  

Mol Cell Proteomics, 2017, 16:1789-1800 (Editors' Highlight)  Link  

Systematic and quantitative assessment of hydrogen peroxide reactivity with cysteines across human proteomes.

Fu L†, Liu K†, Sun M, Sun R, Tian C, Bentanzos C, Tallman KA, Porter NA, Yang Y, Guo D, Liebler DC, Yang J*

Mol Cell Proteomics, 2017, 16:1815-1828 Link 

Preprint Articles

Other Research Articles

Reaction-based fluorogenic probes for selective detection of cysteinyl oxidation in living cells.

Ferreira R, Fu L, Yang J, Carroll KS*.

Nat Commun, 2022, 13: 5522  Link

Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics.

Li Z †, Liu K †, Xu P, Yang J*.

J Proteome Res. 2022, 21: 1349–1358 Link

Rice GLUTATHIONE PEROXIDASE1-mediated oxidation of bZIP68 positively regulates ABA-independent osmotic stress signaling.

Zhou H, Zhang F, Zhai F, Su Y, Zhou Y, Ge Z, Tilak P, Eirich J, Finkemeier I, Fu L, Li Z, Yang J, Shen W, Yuan X, Xie Y*.

Mol Plant, 2021 Nov 15;S1674-2052(21)00437-8 Link

Comment on "Evidence that the ProPerDP method is inadequate for protein persulfidation detection due to lack of specificity"
Dóka E, Arnér ESJ, Schmidt EE, Dick TP, van der Vliet A, Yang J, Szatmári R, Ditrói T, Wallace JL, Cirino G, Olson K, Motohashi H, Fukuto JM, Pluth MD, Feelisch M, Akaike T, Wink DA, Ignarro LJ, Péter Nagy*.
Sci Adv, 2021, 7(17): eabe7006 Link

Hydrogen Sulfide-linked Persulfidation of ABSCISIC INSENSITIVE 4 Controls Arabidopsis ABA Responses Through the Transactivation of Mitogen-Activated Protein Kinase Kinase Kinase 18.
Zhou M, Zhang J, Shen J, Zhou H, Zhao D, Gotor C, Romero LC, Fu L, Li Z, Yang J, Shen W, Yuan X, Xie Y*.
Mol Plant, 2021, S1674-2052(21): 00082-4 Link

Endogenous SO2-dependent Smad3 redox modification controls vascular remodeling.

Huang Y, Li Z, Zhang L, Tang H, Zhang H, Wang C, Chen S, Bu D, Zhang Z, Zhu Z, Yuan P, Li K, Yu X, Kong W, Tang C, Jung Y, Ferreira R, Carroll KS, Du J, Yang J*, Jin H*.

Redox Biol, 2021, 41: 101898. Link

Structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex.

Ping YQ†, Mao C†, Xiao P†, Zhao RJ†, Jiang Y†, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao XN, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE*, Zhang Y*, Sun JP*. 

Nature, 2021, 589: 620-626. Link

An Arabidopsis Secondary Metabolite Directly Targets Expression of the Bacterial Type III Secretion System to Inhibit Bacterial Virulence.

Wang W†, Yang J†, Zhang J, Liu Y, Tian C, Qu B, Gao C, Xin P, Chen S, Zhang W, Miao P, Li L, Zhang X, Chu J, Zuo J, Li J, Bai Y, Lei X*, Zhou J*.

Cell Host Microbe. 2020, 27(4): 601-613. Link

A clickable APEX probe for proximity-dependent proteomic profiling in yeast.

Li Y, Tian C, Liu K, Zhou Y, Yang J*, Zou P*.

Cell Chem Biol. 2020, 27(7): 858-865. Link

Persulfidation-based modification of cysteine desulfhydrase and the NADPH oxidase RBOHD controls guard cell abscisic acid signaling.

Shen J†, Zhang J†, Zhou M†, Zhou H†, Cui B, Gotor C, Romero LC, Fu L, Yang J, Foyer CH, Pan Q, Shen W, Xie Y*.

Plant Cell. 2020, 32(4):1000-1017 Link

Mining for protein S-sulfenylation in Arabidopsis uncovers redox-sensitive sites. 

Huang J † , Willems P † , Wei B † , Tian C, Ferreira R, Bodra N, Gache S, Wahni K, Liu K, Vertommen D, Gevaert K, Carroll KS, Van Montagu M*, Yang J*, Van Breusegem F*, Messens J*.

Proc Natl Acad Sci U S A, 2019, 116 (42): 21256-21261. Link

Diurnal oscillations of endogenous H2O2 sustained by p66Shc regulate circadian clocks. 

Pei J, Li X, Li W, Gao Q, Zhang Y, Wang X, Fu J, Cui S, Qu J, Zhao X, Hao D, Ju D, Liu N, Carroll KS, Yang J, Zhang EE, Cao J, Chen H*, Liu D*.  

Nat Cell Biol.  2019, 21(12): 1553-1564 Link

Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair.

Yang W†, Tao Y†, Wu Y, Zhao X, Ye W, Zhao D, Fu L, Tian C, Yang J, He F*, Tang L*.

Nat Commun. 2019, 10(1): 1076 Link

Proteome‐Wide Analysis of Cysteine S‐Sulfenylation Using a Benzothiazine‐Based Probe.

Fu L†, Liu K† , Ferreira RB, Carroll KS, Yang J*.

Curr Protoc Protein Sci.  2019, 95(1): e76 Link

Dynamic Redox Balance Directs the Oocyte-to-Embryo Transition via Developmentally Controlled Reactive Cysteine Changes.

Petrova B, Liu K, Tian C, Kitaoka M, Freinkman E, Yang J*, Orr-Weaver TL*.

Proc Natl Acad Sci U S A. 2018, 115 (34): E7978-E7986 Link

Chemoproteomics Reveals Unexpected Lysine/Arginine-Specific Cleavage of Peptide Chains as a Potential Protein Degradation Machinery.

Tian C, Liu K, Sun R, Fu L, Yang J*.

Anal Chem. 2018, 90: 794-800 Link

A chemoproteomic platform to assess bioactivation potential of drugs.

Sun R, Shi F, Liu K, Fu L, Tian C, Yang Y, Tallman KA, Porter NA, Yang J*

Chem Res Toxicol. 2017, 30: 1797-1803 Link

Selected publications pre-independence (2007-2015)
*Corresponding author,
Co-first author

The expanding landscape of the thiol proteome.

Yang J*, Carroll KS, Liebler DC*.

Mol Cell Proteomics, 2016, 15: 1-11 Link

Site-specific mapping and quantification of protein S-sulphenylation in cells. 
Yang J, Gupta V, Carroll KS, Liebler DC*.
Nat Commun. 2014, 5: 4776 Link
Global, in situ, site-specific analysis of protein S-sulfenylation. 
Yang J*
, Gupta V, Tallman KA, Porter NA, Carroll KS, Liebler DC*.
Nat Protoc. 2015, 10: 1022-37 Link
Diverse redoxome reactivity profiles of carbon nucleophiles. 
Gupta V†
, Yang J†, Liebler DC, Carroll KS*.
J Am Chem Soc, 2017, 139: 5588−5595 (Highlighted in C&E News) Link 

Quantitative chemoproteomics for site-specific analysis of protein alkylation by 4-hydroxy-2-nonenal in cells.

Yang J, Tallman KA, Porter NA, Liebler DC*.   

Anal Chem. 2015, 87: 2535-41 (Editors' Highlight) Link

Gambogic acid deactivates cytosolic and mitochondrial thioredoxins by covalent binding the functional domain.

Yang J † , Li C † , Ding L*, Guo Q, You Q, Jin S.  

J Nat Prod. 2012, 75: 1108-1116 Link

Metabolism of gambogic acid in rats: a rare intestinal metabolic pathway responsible for its final disposition. 
Yang J, Ding L*, Hu L, Qian W, Jin S, Sun X, Wang Z, Xiao W.
Drug Metab Dispos. 2011, 39: 617-26 Link